Fig. 1
Efficacy of IVIG in active vs. adoptive transfer EAE. B6 mice were immunized with MOG35–55 peptide emulsified in CFA and treated i.p. with IVIG or PBS starting 1 day before immunization and every day thereafter (or as indicated). Titration (a) and timing (b) of IVIG treatment. Means and SEM are shown. n = 4 animals per group. c EAE was induced by adoptive transfer of in vitro restimulated leukocytes derived from MOG35–55 and CFA immunized 2D2 mice. Mice received daily i.p. injections of IVIG or buffer starting 1 day before immunization. Means and SEM are shown. n = 10 animals per group