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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation

Fig. 4

F(ab’)2 treatment impairs innate immune cell activation. B6 mice were either left untreated (naïve) or immunized with MOG35–55 peptide emulsified in CFA and injected i.p. with F(ab’)2 (0.33 g/kg) or buffer starting 1 day before immunization and every day thereafter. Analysis of splenic neutrophils, monocytes, and dendritic cell subsets 9 days after immunization is shown. Frequencies (a) and absolute numbers (b) of the indicated leukocyte subset and cell surface expression levels of MHC class II (c) and CD80 (d). MFI median fluorescence intensity. Statistics were performed by Mann Whitney test. *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001

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