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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: CD200R1 agonist attenuates glial activation, inflammatory reactions, and hypersensitivity immediately after its intrathecal application in a rat neuropathic pain model

Fig. 7

RT-PCR analysis of cytokine RNAs in the spinal cord after CD200Fc administration. Effect of CD200Fc on TNF, IL-1β, IL-6, IL-4, and IL-10 mRNAs expression in L4–L5 segments of spinal cord from sCCI-operated rats for 7 days. sCCI of the sciatic nerve and ACSF treatment increased levels of TNF (a), IL-1β (b), and IL-6 (c) as well as decreased IL-4 (d) and IL-10 (e) mRNA expression in the lumbar spinal cord segments. Intrathecal CD200Fc administration prevented the increase of TNF, IL-1β, and IL-6 as well as the decrease of IL-4 and IL-10 mRNAs expression in the lumbar spinal cord segments. The mRNA expression of each gene (n = 6 per group) was normalized to that of the 18S gene and the data represent the mean ± SD. *p < 0.05, **p < 0.001 when compared to naïve rats; +p < 0.05, ++p < 0.001 when compared to sham-operated rats; #p < 0.05 when compared to sCCI + ACSF rats. Mann-Whitney U test

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Journal of Neuroinflammation

ISSN: 1742-2094