From: HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS
Cx43 expression in astrocytes (percentage of control, n = 5) | ||||
---|---|---|---|---|
Treatment (virus) | 7 days | 14 days | 21 days | 28 days |
HIVADA (20Â ng/ml) | No change | No change | No change | No change |
HIVJR-CSF (20Â ng/ml) | No change | No change | No change | No change |
Treatment (recombinant proteins) | 6Â h | 12Â h | 24Â h | 48Â h |
Vif (1, 100, and 300Â ng/ml) | No change | No change | No change | No change |
Gag (p55, p24, or p7: 1, 100, and 300Â ng/ml) | No change | No change | No change | No change |
Rev (1, 100, and 250Â ng/ml) | No change | No change | No change | No change |
Nef (1, 100, and 250Â ng/ml) | No change | No change | No change | No change |
Gp120 (1, 50, and 100 nM) | −8.6 ± 1.3* | −5.4 ± 3.2* | −4.1 ± 1.2* | −3.1 ± 0.5* |
HIV-tat1–72 (1, 100, and 300 ng/ml) | 45.1 ± 12.3* | 21.3 ± 8* | 21.1 ± 2.2* | 25.1 ± 2.5* |
IL-1β (10 ng/ml) | −10.2 ± 5.2* | −16 ± 6.89* | −61.3 ± 11* | −69.9 ± 12.6* |