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Table 1 Expression of Cx43 by astrocytes after different HIV treatments

From: HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS

Cx43 expression in astrocytes (percentage of control, n = 5)
Treatment (virus) 7 days 14 days 21 days 28 days
HIVADA (20 ng/ml) No change No change No change No change
HIVJR-CSF (20 ng/ml) No change No change No change No change
Treatment (recombinant proteins) 6 h 12 h 24 h 48 h
Vif (1, 100, and 300 ng/ml) No change No change No change No change
Gag (p55, p24, or p7: 1, 100, and 300 ng/ml) No change No change No change No change
Rev (1, 100, and 250 ng/ml) No change No change No change No change
Nef (1, 100, and 250 ng/ml) No change No change No change No change
Gp120 (1, 50, and 100 nM) −8.6 ± 1.3* −5.4 ± 3.2* −4.1 ± 1.2* −3.1 ± 0.5*
HIV-tat1–72 (1, 100, and 300 ng/ml) 45.1 ± 12.3* 21.3 ± 8* 21.1 ± 2.2* 25.1 ± 2.5*
IL-1β (10 ng/ml) −10.2 ± 5.2* −16 ± 6.89* −61.3 ± 11* −69.9 ± 12.6*
  1. Although we used three different concentrations for each HIV protein, no significant differences were detected among them. Thus, we combined the data from the three different concentrations
  2. *p ≤ 0.05 (n = 4)