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Table 1 Expression of Cx43 by astrocytes after different HIV treatments

From: HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS

Cx43 expression in astrocytes (percentage of control, n = 5)

Treatment (virus)

7 days

14 days

21 days

28 days

HIVADA (20 ng/ml)

No change

No change

No change

No change

HIVJR-CSF (20 ng/ml)

No change

No change

No change

No change

Treatment (recombinant proteins)

6 h

12 h

24 h

48 h

Vif (1, 100, and 300 ng/ml)

No change

No change

No change

No change

Gag (p55, p24, or p7: 1, 100, and 300 ng/ml)

No change

No change

No change

No change

Rev (1, 100, and 250 ng/ml)

No change

No change

No change

No change

Nef (1, 100, and 250 ng/ml)

No change

No change

No change

No change

Gp120 (1, 50, and 100 nM)

−8.6 ± 1.3*

−5.4 ± 3.2*

−4.1 ± 1.2*

−3.1 ± 0.5*

HIV-tat1–72 (1, 100, and 300 ng/ml)

45.1 ± 12.3*

21.3 ± 8*

21.1 ± 2.2*

25.1 ± 2.5*

IL-1β (10 ng/ml)

−10.2 ± 5.2*

−16 ± 6.89*

−61.3 ± 11*

−69.9 ± 12.6*

  1. Although we used three different concentrations for each HIV protein, no significant differences were detected among them. Thus, we combined the data from the three different concentrations
  2. *p ≤ 0.05 (n = 4)