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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis

Fig. 3

Anti-TNF treatment ameliorates progressive EAE. EAE was induced in WT and GFAP∆R1γ mice. At the peak of acute disease (d19 p.i.), WT and GFAP∆R1γ were divided into two groups with equal clinical scores. WT + αTNF and GFAP∆R1γ + αTNF received i.p. injections of anti-TNF mAb (0.5 mg), whereas WT and GFAP∆R1γ received equal amounts of isotype mAb control. Mice were treated every 2 days for a total of four dosages. a Clinical scores of αTNF treated and control cohorts pre and 10 days post treatment b Kinetics of clinical recovery and c percent survival in anti-TNF treated GFAP∆R1γ mice relative to control treated GFAP∆R1γ and WT mice. Data represent the mean values and ± SEM of four separate experiments with five mice per group per experiment. P values are determined by Student’s t test. d Percentage area of demyelination in spinal cord white matter calculated by analysis of transverse sections at six separate levels per mouse. Data represent the mean ± SEM of seven to nine individual mice per group. Statistical differences determined by two-tailed unpaired t test with *p < 0.05

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