Fig. 6

TNF neutralization promotes anti-inflammatory responses. a MHC class II expression on macrophages and microglia derived from WT and GFAPγR1∆ mice treated with α-TNF or control mAb determined by flow cytometry at d30p.i. b IL-10 levels in the CNS of mouse groups as depicted determined by ELISA (D30p.i.). Foxp3 (c) and IL-27p28 (d) mRNA expression in the CNS determined by RT-PCR. Data represent the mean values and ± SEM of three separate experiments with five mice per group per experiment. P values determined by Student’s t test