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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina

Fig. 6

Effect of NR58-3.14.3 on the pathogenic phenotype of the retinal macrophage population following light damage. a Representative FACS plots, with gating strategies for the isolation of CD11b+ macrophages/microglia. Gating methodology was applied equally for all samples. b Representative images of PCR products via electrophoresis for chemokine receptors Ccr1, Ccr2, Ccr5, and Cxcr3, in samples of CD11b-sorted cells. Receptor expression was observed in both NR58-3.14.3 and PBS CD11b isolates. c Following exposure to LD, expression of Ccl3, Ccl4, and Il6 were all decreased in CD11b+ macrophages isolated from NR58-3.14.3-injected retinas, compared to those from PBS-injected retinas (P < 0.05). N = 5 per group at 0 day

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