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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina

Fig. 7

In situ hybridisation for Ccl3 mRNA following NR58-3.14.3 injections and light damage. a, b At 0 day LD recovery in PBS-injected retinas, there was staining for Ccl3 mRNA (purple) in among clusters of irregularly shaped nuclei traversing the ONL (arrows). c, d Retinas injected NR58-3.14.3, conversely, displayed very few Ccl3-expressing nuclei. e, f Ccl3-expressing nuclei (red, arrow) correlated strongly with immunofluorescence for IBA1+ macrophages/microglia (green, arrow). IHC immunohistochemistry, ISH in situ hybridisation, ONL outer nuclear layer, OS outer segments. Scale bars represent 50 μm

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Journal of Neuroinflammation

ISSN: 1742-2094