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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Celastrol protects mouse retinas from bright light-induced degeneration through inhibition of oxidative stress and inflammation

Fig. 2

Celastrol preserved retinal function and protected against photoreceptor apoptosis in light-exposed BALB/c mice. a Dark-adapted BALB/c mice were exposed to light at the intensity of 10,000 lx for 30 min after pretreatment with DMSO and celastrol at 5 mg/kg bw. Retinal function was examined by ERG 4 days after light exposure. Scotopic ERG was recorded and both a-waves and b-waves were plotted to evaluate retinal function. Data were expressed as mean ± S.E.M. (n = 4 per group). *Compared to that from no light, p < 0.05; #compared to DMSO, p < 0.05. b Dark-adapted BALB/c mice were exposed to light at 10,000 lx for 2 h after pretreatment with either DMSO or celastrol. Cryosections were made from eye cups collected from mice 3 h, 1 day, 3 days, and 7 days after light exposure along with those from the mice without light exposure (no light). Apoptosis was then examined by TUNEL staining (in green) and DAPI counterstaining (in blue) (n = 3–5 per group). ONL outer nuclear layer, INL inner nuclear layer. Scale bar: 50 μm

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