Fig. 5

Celastrol suppressed light-induced expression of COX2 in photoreceptors. Dark-adapted BALB/c mice were exposed to light at 10,000 lx for 2 h after pretreatment with either DMSO or celastrol at 5 mg/kg bw. Eyes cups were made from enucleated eyes collected 1 and 7 days after light exposure. Cryosections were subject to IHC examination of COX2 expression (in red) and counterstained by DAPI (in blue) (n = 3–5 per group). ONL outer nuclear layer, INL inner nuclear layer. Scale bar: 50 μm