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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice

Fig. 2

Blockage of Nogo/NgR pathway attenuated amyloidogenic and induced non-amyloidogenic processing of APP in APP/PS1 mice. Homogenates from the brain tissue of 8-month-old APP/PS1 transgenic mice were subjected to western blot analysis with markers of APP expression and processing. a, b APP. c, d BACE1. e, f β-CTF. g, h ADAM10. i, j PS1 loop. Values were reported as mean ± SD, as a percentage of values determined in the vehicle group (control, 100 %). ***p < 0.001, when compared with the vehicle group, n = 3–6

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Journal of Neuroinflammation

ISSN: 1742-2094