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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice

Fig. 6

The CM derived from Nogo/NgR-activated BV-2 microglia increased the expression and amyloidogenic processing of APP. Neurons were exposed for CM of BV-2 microglia at different treatments for 24 h. The expression of APP (a, b), BACE1 (a, c), ADAM10 (e, f), and PS1 loop (e, h) was determined using western blot. Values were reported as mean ± SD, as a percentage of values determined in the PBS group (control, 100 %). FRET assay was performed to detect the activity of β-secretase (d), α-secretase (g), and γ-secretase (i). Values were reported as mean ± SD, as a percentage of values determined in the PBS group (control, 100 %). *p < 0.05, **p < 0.01, ***p < 0.01, n = 3

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