Fig. 5

TO901317 did not affect LXR expression but increased the LXR target gene, ABCA-1 protein expression post-ICH. Representative immunoblots of a LXR-α, b LXR-β, and c ABCA-1 proteins in the ipsilateral hemisphere of sham-injured, vehicle-treated, and 30 mg/kg TO901317-treated mice at 4 days post-ICH. Bar graphs of densitometric analysis of bands show that TO901317 did not affect either LXR-α or LXR-β protein expression but increased the LXR target gene, ABCA-1 protein expression. Values are mean ± SEM; ^** P < 0.01, and ^*** P < 0.001 versus sham group, ^# P < 0.05 versus vehicle group (n = 5–7 mice/group, one-way ANOVA for LXRs and Student’s t test for ABCA-1 western blot).