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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Treatment with TO901317, a synthetic liver X receptor agonist, reduces brain damage and attenuates neuroinflammation in experimental intracerebral hemorrhage

Fig. 7

TO901317 reduced expression of inflammatory mediators in mice after ICH. Bar graphs of a MCP-1, b MIP-2, and c IL-6 protein concentrations, as assessed by ELISA in ipsilateral hemispheres of sham control, vehicle-treated, and 30 mg/kg TO901317-treated mice at 4 and 7 days post-ICH. TO901317-treated mice exhibited significantly reduced MCP-1, MIP-2, and IL-6 protein levels compared with vehicle-treated mice at 4 and 7 days. Representative immunoblots of d iNOS and e COX-2 proteins in ipsilateral hemispheres of sham control, vehicle-treated, and 30 mg/kg TO901317-treated mice at 4 days post-ICH. Bar graphs of densitometric analysis of bands show a significant decrease of iNOS and COX-2 protein levels in ipsilateral hemispheres of TO901317-treated mice, compared with vehicle-treated mice. Values are presented as means ± SEM; ** P < 0.01 and ***P < 0.001 versus sham control; # P < 0.05, ## P < 0.01, ### P < 0.001 versus vehicle group (n = 6–7 mice/group, one-way ANOVA)

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