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Table 1 Summary of hyperthermia, reactive microglia, and neurodegeneration after METH exposure

From: Vascular-directed responses of microglia produced by methamphetamine exposure: indirect evidence that microglia are involved in vascular repair?

     Brain regions
     Septum Hippocampus Thalamus Parietal cortex
Rat ID Time point (days) Peak BT (°C) Times BT ≥ 41.7 °C aFJc labeling bActivated microglia aFJc+ labeling bActivated microglia cFJc labeling bActivated microglia cFJc labeling bActivated microglia
FG278 3ys 41.6 1
FG279 3 41.0 1
FG230 3 42.0 4
FG288 3 41.9 20 ++ 2
FG227 3 42.2 + +++ +++ 17 + 8 +
FG268 3 42.6 3 10 +
FG298 3 42.0 + + 5 + 10 +
FG289 3 42.7 + 38 +++ 9 +
FG269 3 42.6 + + 27 ++ 2
FG228 3 42.3 + +++ ++++ 132 ++++ 7 +
FG267 3 42.3 + ++++ ++++ 37 +++ 4 +
FG291 3 42.2 + ++++ ++++ 91 ++++ 12 +
FG311 3 42.4 + +++ ++ 53 +++ 7 +
FG258 1 41.9 0 3
FG259 1 42.3 6 6
FG260 1 42.1 0 3
FG310 1 42.2 +? +? +? +? 53 6
  1. Data relating to neurodegeneration or microglia activation for the four control animals is not shown since it was all negative. The correlation between the numbers of times body temperature was ≥41.7 °C, and the relative number of activated microglia within a region was determined using the Spearman rank-order correlation method. The correlation coefficients were as follows: septum, r = 0.781, p = 0.0008; hippocampus, r = 0.850, p < 0.00001; thalamus, r = 0.927, p < 0.00001; parietal cortex, r = 0.652, p < 0.014. The correlation between the numbers of times body temperature was ≥41.7 °C and the relative number of FJc within a region was determined using the Pearson product-moment correlation. The correlation coefficients were as follows: thalamus, r = 0.714, p = 0.0061; parietal cortex, r = 0.546, p = 0.054 not significant
  2. aFJc positive fibers (>10 per 25-μm section per hemisphere) observed in the medial septum
  3. bRelative number of activated Iba1 immunoreactive cells/microglia per 25-μm section per hemisphere such that per region per hemisphere: (−) indicates <5 cells per region; (+) 5 to 20 cells; (++) 20 to 100 cells; (+++) >100 cells
  4. cFJc positive cells per 25-μm section per hemisphere observed in thalamus or parietal cortex