Table 1 Summary of hyperthermia, reactive microglia, and neurodegeneration after METH exposure
Brain regions | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Septum | Hippocampus | Thalamus | Parietal cortex | ||||||||
Rat ID | Time point (days) | Peak BT (°C) | Times BT ≥ 41.7 °C | aFJc labeling | bActivated microglia | aFJc+ labeling | bActivated microglia | cFJc labeling | bActivated microglia | cFJc labeling | bActivated microglia |
FG278 | 3ys | 41.6 | − | − | − | − | − | − | − | 1 | − |
FG279 | 3 | 41.0 | − | − | − | − | − | − | − | 1 | − |
FG230 | 3 | 42.0 | 2× | − | − | − | − | − | − | 4 | − |
FG288 | 3 | 41.9 | 3× | − | − | − | − | 20 | ++ | 2 | − |
FG227 | 3 | 42.2 | 3× | + | +++ | − | +++ | 17 | + | 8 | + |
FG268 | 3 | 42.6 | 3× | − | − | − | − | 3 | − | 10 | + |
FG298 | 3 | 42.0 | 3× | − | + | − | + | 5 | + | 10 | + |
FG289 | 3 | 42.7 | 4× | − | − | − | + | 38 | +++ | 9 | + |
FG269 | 3 | 42.6 | 4× | − | + | − | + | 27 | ++ | 2 | − |
FG228 | 3 | 42.3 | 5× | + | +++ | − | ++++ | 132 | ++++ | 7 | + |
FG267 | 3 | 42.3 | 5× | + | ++++ | − | ++++ | 37 | +++ | 4 | + |
FG291 | 3 | 42.2 | 5× | + | ++++ | − | ++++ | 91 | ++++ | 12 | + |
FG311 | 3 | 42.4 | 5× | + | +++ | − | ++ | 53 | +++ | 7 | + |
FG258 | 1 | 41.9 | 2× | − | − | − | − | 0 | − | 3 | − |
FG259 | 1 | 42.3 | 3× | − | − | − | − | 6 | − | 6 | − |
FG260 | 1 | 42.1 | 3× | − | − | − | − | 0 | − | 3 | − |
FG310 | 1 | 42.2 | 4× | +? | +? | +? | +? | 53 | − | 6 | − |