Fig. 3

MiR-7 is indispensable for the protection of nicorandil against OGD-induced injury. Dose response of miR-7 level in primary cultured astrocytes after transfection with miR-7 mimic (a) and/or inhibitor (b). c Herpud2 mRNA level in primary cultured astrocytes transfected with miR-7 mimic and inhibitor. d Cell viability of astrocytes after pretreatment with nicorandil and (or) miR-7 inhibitor. Data are represented as means ± S.E.M. from four independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001 vs. control; ^# P < 0.05, ^### P < 0.001 vs. OGD group; ^$$ P < 0.01 vs. OGD plus nicorandil pretreatment group