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Table 2 Cytokines level at 540 m and at 3860 m (hypoxia)

From: Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia

  TNF-α IL-1β IL-6 (pg/ml) N
Symptoms 540 m 3860 m 540 m 3860 m 540 m 3860 m 74
No-AMS:
 A (no symptom) 15.09 ± 0.51 (3.22) 19.39 ± 1 (6.33)*** 3.43 ± 0.63 (2.1) 5.07 ± 0.98 (3.24)*** 7.51 ± 0.36 (2.28) 11.43 ± 0.8 (5.06)*** 40
 B (headache only) 17.57 ± 2.25 (5.52) 22.7 ± 2.83 (6.94)* 4.1 ± 0.81 (1.98) 7.23 ± 1.01 (2.48) 8.57 ± 0.98 (2.4) 18.27 ± 3.65 (8.94)*,+ 6
 C (headache + 1 symptom) 16.64 ± 3.24 (5.61) 20.31 ± 4.55 (7.88) 4.32 ± 0.37 (0.64) 10.22 ± 2.51 (4.35)$ 7.85 ± 1.23 (2.13) 15.2 ± 2.59 (4.48) 3
 D (other symptoms) 15.46 ± 1.18 (4.4) 20.96 ± 1.32 (4.92)*** 4.52 ± 0.58 (2.16) 7.12 ± 0.55 (2.07)***,@ 7.47 ± 0.57 (2.12) 13.32 ± 1.49 (5.57)**, & 14
AMS:
 E (headache + 2 symptoms) 15.23 ± 1.24 (4.11) 25.59 ± 2.84 (9.42)**, # 3.34 ± 0.46 (1.51) 7.65 ± 0.85 (2.83)***,# 8.14 ± 0.76 (2.53) 20.62 ± 2.5 (8.29)***,### 11
  1. Values are presented means ± SE (SD)
  2. *P < 0.05; **P < 0.01; ***P < 0.001 compared with cytokines level of same group at 540 m
  3. # P < 0.05; ### P < 0.001 compared with A group (TNF, P = 0.013; IL-1, P = 0.02; IL-6, p = 7.6 × 10−5) at 3860 m
  4. + P < 0.017; compared with A group at 3860 m by Bonferroni’s multiple comparisons test after correction (IL-6, A vs B P = 0.008)
  5. $ P < 0.017, trends by 0.017 < @ P < 0.05 (IL-1, A vs C, P = 0.013; A vs D P = 0.03)
  6. & P < 0.05 compared with E group (D vs E, P = 0.02) at 3860 m