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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells

Fig. 1

CXCR3−/− mice develop more severe EAE. EAE was induced in WT (n = 11) and CXCR3−/− (n = 11) mice by immunizing with MOG/CFA. a Clinical scores of WT and CXCR3−/− mice at various times after immunization are shown. Data are representative of six independent experiments (*P < 0.05). b Sections of the lumbar spinal cord (original magnification ×100) collected from WT and CXCR3−/− mice at the peak of disease (day 15) were fixed and subjected to LFB staining followed by counterstaining with cresyl violet for detection of demyelination (blue) and inflammation (purple). Arrows indicate infiltrating leukocytes. n stands for the number of mice

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Journal of Neuroinflammation

ISSN: 1742-2094