Skip to main content
Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus

Fig. 4

Blood-brain barrier permeability and microglial activation in B cell-deficient and B cell-depleted lupus mice. a Albumin staining was performed in the brain sections from MRL/lpr (n = 6), JhD/MRL/lpr (n = 4), hCD20-DTA/MRL/lpr (n = 7), and MRL/MPJ (n = 7) mice, all at 19 weeks of age. Representative images of albumin leakage around the vessels (indicated by arrows) in the cortex are shown. Percentages (%) of mice in each group that are positive for albumin leakage were displayed. Albumin staining was repeated twice, with similar results. b Iba-1 staining was performed on the brain sections of MRL/lpr (n = 6), JhD/MRL/lpr (n = 4), hCD20-DTA/MRL/lpr (n = 7), and MRL/MPJ (n = 7) mice, all at 19 weeks of age. Representative images of Iba-1 staining in the cortex are shown. Fold changes of fluorescence intensity are shown in the bottom panel, with the mean of MRL/MPJ set at 1. Iba-1 staining was repeated twice, with similar results. The scale bar in each image represents 20 μm

Back to article page