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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: B cell and/or autoantibody deficiency do not prevent neuropsychiatric disease in murine systemic lupus erythematosus

Fig. 5

Brain cell apoptosis and hippocampal gliosis in JhD/MRL/lpr and hCD20-DTA/MRL/lpr mice. TUNEL and GFAP staining was performed in MRL/lpr (n = 6), JhD/MRL/lpr (n = 4), hCD20-DTA/MRL/lpr (n = 7), and MRL/MPJ (n = 7) mice, all at 19 weeks of age. Representative images of TUNEL staining in periventricular areas and choroid plexus are shown in (a, top panels). Quantitation of the average number of TUNEL positive cells in the two brain sections from each mouse is indicated in the bottom panel. b Representative images of GFAP staining in the hippocampus. Fold changes of fluorescence intensity are shown in the bottom panel, with the mean of MRL/MPJ set at 1. TUNEL and GFAP staining were repeated twice, with similar results. The scale bar in each image represents 40 μm

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