Fig. 5
From: Complement activation at the motor end-plates in amyotrophic lateral sclerosis
Representative confocal triple-immunofluorescence for neurofilament (NF-H, Cy3), end-plates detected with α-BTX (Alexa 488) and the regulator CD59 (Cy5) in control (a, b, c, d) and ALS (e, f, g, h) intercostal muscle showing deposition of CD59 (white asterisks in h, enlarged in insert) in ALS intercostal muscle tissue on denervated end-plates (white arrow pointing to α-BTX and arrowhead pointing to NF-H in h) but not in controls. Quantification shows CD59-positive innervated and denervated motor end-plates in the intercostal muscle of ALS donors but not in controls (P = 0.05 and P = 0.05, respectively) (i). Data represents standard deviation of the mean. n.d. not detected