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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

Fig. 1

Lipoxin A4 attenuates mechanical allodynia induced by spinal cord hemisection in mice. a Treatment scheme for intrathecal injections of lipoxin A4 or vehicle and behavioral analyses. b, e Following SCI, adult mice develop mechanical allodynia in both ipsilateral and contralateral hindpaws. Fifty percent paw withdrawal thresholds are increased with LXA4 administration at 4 and 24 h, compared to vehicle-treated group. An additional intrathecal bolus injection of 300 pmol of LXA4 at 35 days still attenuated mechanical allodynia in both ipsilateral and contralateral paws from 3 h up to 24 h. c, fd, g The area under the curve depicting variations of 50 % paw withdrawal thresholds in time are presented for treatment evaluation up to 35 days and after the bolus injection. Results are presented as mean ± SEM. Asterisk denotes p < 0.05 when comparing to sham-operated group and number sign denotes p < 0.05 when comparing to vehicle-treated group (two-way ANOVA followed by Bonferroni; n = 6 mice/group)

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