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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

Fig. 3

LXA4 attenuates the SCI-induced microglial reactivity in the spinal cord. Lipoxin A4 reduces the SCI-induced increase in Iba-1 expression in the spinal cord at 7 and 36 days after surgery. Staining for Iba-1 (red, a), GFAP (green, b), and DAPI (blue) in thoracic spinal cord from sham, vehicle-treated SCI, or LXA4-treated SCI mice. Scale 200 μm. Iba-1 staining was enhanced at 7 (a, b) and 36 days (d, e) after SCI and was reduced by LXA4 treatment. GFAP expression was significantly upregulated by SCI at 7 (ac) and 36 days (df) but was not changed following LXA4 administration. Results shown in graphs are presented as mean ± SEM. Asterisk denotes p < 0.05 when comparing to sham-operated group. Number sign denotes p < 0.05 when comparing with vehicle-treated group (Student’s t test, n = 6 mice/group)

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