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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

Fig. 4

Lipoxin A4 reduces the expression of microglial markers and TNF-α. ah Spinal cord injury promotes a significant upregulation of ALX/FPR2 receptors, GFAP, IBA-1, P2Y12, TNF-α, IL-6, iNOS, and TGF-β mRNA levels 7 days post-surgery, comparing to sham-operated mice. ce LXA4 significantly reduced IBA-1, P2Y12, and TNF-α mRNA levels. Data is expressed as mean ± SEM. Asterisk denotes p < 0.05 when comparing to sham-operated group. Number sign denotes p < 0.05 when comparing with vehicle-treated group (one-way ANOVA followed by Bonferroni; n = 4 mice/group)

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