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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Lipoxin A4 inhibits microglial activation and reduces neuroinflammation and neuropathic pain after spinal cord hemisection

Fig. 5

Lipoxin A4 attenuates microglial activation in primary cultures. a Microglia cells stained for DAPI (blue) and ALX/FPR2 receptor (red). Scale 50 μm. b Representative image of ALX/FPR2 mRNA expression on the spinal cord and microglia and astrocytes cultures. c LXA4 reduced p-p38 increase induced by IFN-γ. d IFN-γ induces a significant increase in TNF-α release, which is reduced by both concentrations of LXA4. Data is expressed as mean ± SEM. Asterisk denotes p < 0.05 when comparing to control. Number sign denotes p < 0.05 when comparing with vehicle (one-way ANOVA followed by Bonferroni; n = 4 cultures)

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