Fig. 1

Intermittent ocular hypertension: Induction of short-term elevated intraocular pressure. a Eyes of anesthetized Long Evans rats were injured by inducing elevated intraocular pressure levels using a silicone loop around the bulb for 1 h per day for 27 treatments. The loop is attached very gently around the eye without modifying the shape of the eye (white arrow) and held in place using a stand. Eyes were kept moist during the time of the experiment. Left eyes served as fellow control eyes. b A schematic of the anatomic details of a rodent eye without (b) and with the loop attached (b’). The loop slightly compresses Schlemm’s canal (SC) as well as the episcleral veins (in lighter gray) and provokes a marginal relocation of the iridocorneal angle (indicated by the arrow), resulting in an increase of aqueous humor outflow resistance. Abbreviations: C cornea, I iris, CB ciliary body, S sclera