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Table 1 Summary of the densities of the axons, retinal ganglion cells, microglia, and IgG depositions

From: Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma

Group

Number of axons per 0.05 mm2 ± SD (n of optic nerves)

p vs control

p vs iOHT injured eye

Brn3a-positive cells per mm retina ± SD (n of eyes)

p vs control

p vs iOHT injured eye

Iba1-positive cells per mm retina ± SD (n of eyes)

p vs control

p vs iOHT injured eye

IgG depositions per mm retina ± SD (n of eyes)

p vs control

p vs iOHT injured eye

Control eyes

22,267 ± 1408 (12)

 

0.0003

95.2 ± 12.6 (13)

 

0.0001

5.2 ± 1.1 (14)

 

0.01

0.5 ± 0.4 (14)

 

0.002

iOHT fellow eye

21,943 ± 1510 (12)

0.98

0.001

82.0 ± 9.9 (11)

0.07

0.02

6.7 ± 1.3 (10)

0.03

1

1.1 ± 0.4 (10)

0.045

0.75

iOHT injured eye

19,624 ± 1709 (12)

0.0003

 

66.0 ± 13.2 (11)

0.0001

 

6.7 ± 1.3 (12)

0.01

 

1.3 ± 0.6 (10)

0.002

 

iOHT + Belimumab fellow eye

21,838 ± 802 (9)

0.96

0.008

80.9 ± 10.0 (9)

0.08

0.06

6.6 ± 1.0 (9)

0.08

0.99

0.9 ± 0.2 (9)

0.3

0.3

iOHT+ Belimumab injured eye

20,593 ± 609 (9)

0.07

0.5

74.2 ± 9.5 (8)

0.005

0.6

6.5 ± 1.0 (8)

0.1

0.99

0.9 ± 0.4 (8)

0.3

0.4

  1. Analysis after 27 treatments using intermittent ocular hypertension shows the number of axons per 0.05 mm2 for all groups. These data illustrate the damage of optic nerves, and the number of Brn3a-positive cells indicate the overall density of retinal ganglion cells. Furthermore, the Iba1-positive cells imply the activation of microglia and immunoglobulin G (IgG) depositions, displaying the occurrence of autoantibody depositions. Brn3a, Iba1, and IgG data are given as total cell numbers per mm retina ± standard deviation (SD), and the number of animals in the analyses (n) are displayed. Statistically significant p values are highlighted in italics