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Table 1 Summary of the densities of the axons, retinal ganglion cells, microglia, and IgG depositions

From: Immune response after intermittent minimally invasive intraocular pressure elevations in an experimental animal model of glaucoma

Group Number of axons per 0.05 mm2 ± SD (n of optic nerves) p vs control p vs iOHT injured eye Brn3a-positive cells per mm retina ± SD (n of eyes) p vs control p vs iOHT injured eye Iba1-positive cells per mm retina ± SD (n of eyes) p vs control p vs iOHT injured eye IgG depositions per mm retina ± SD (n of eyes) p vs control p vs iOHT injured eye
Control eyes 22,267 ± 1408 (12)   0.0003 95.2 ± 12.6 (13)   0.0001 5.2 ± 1.1 (14)   0.01 0.5 ± 0.4 (14)   0.002
iOHT fellow eye 21,943 ± 1510 (12) 0.98 0.001 82.0 ± 9.9 (11) 0.07 0.02 6.7 ± 1.3 (10) 0.03 1 1.1 ± 0.4 (10) 0.045 0.75
iOHT injured eye 19,624 ± 1709 (12) 0.0003   66.0 ± 13.2 (11) 0.0001   6.7 ± 1.3 (12) 0.01   1.3 ± 0.6 (10) 0.002  
iOHT + Belimumab fellow eye 21,838 ± 802 (9) 0.96 0.008 80.9 ± 10.0 (9) 0.08 0.06 6.6 ± 1.0 (9) 0.08 0.99 0.9 ± 0.2 (9) 0.3 0.3
iOHT+ Belimumab injured eye 20,593 ± 609 (9) 0.07 0.5 74.2 ± 9.5 (8) 0.005 0.6 6.5 ± 1.0 (8) 0.1 0.99 0.9 ± 0.4 (8) 0.3 0.4
  1. Analysis after 27 treatments using intermittent ocular hypertension shows the number of axons per 0.05 mm2 for all groups. These data illustrate the damage of optic nerves, and the number of Brn3a-positive cells indicate the overall density of retinal ganglion cells. Furthermore, the Iba1-positive cells imply the activation of microglia and immunoglobulin G (IgG) depositions, displaying the occurrence of autoantibody depositions. Brn3a, Iba1, and IgG data are given as total cell numbers per mm retina ± standard deviation (SD), and the number of animals in the analyses (n) are displayed. Statistically significant p values are highlighted in italics