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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury

Fig. 8

EVT901 treatment improved motor function and reduced brain damage after TBI. a Persistent fine motor coordination was evaluated by beam walking for 6 weeks after TBI. The total number of footfaults was increased by TBI, and EVT901 reduced this deficit. Two-way ANOVA revealed a significant main effect of injury (F 1,26 = 48.996, p = 0.0000002, η 2 = 0.65, power = 1), and a significant time × treatment effect (F 3,78 = 4.90, p = 0.04, η 2 = 0.16, power = 0.9). Tukey’s post hoc tests revealed a significant difference between TBI-vehicle and TBI-EVT901 (*p = 0.04) and sham and TBI (### p < 0.0001). b Unbiased stereological volumetric analysis showed a significant atrophy of cortex on the ipsilateral, but not contralateral side of TBI. EVT901 treatment inhibited tissue atrophy compared to vehicle. T test (* p = 0.04). (n = 5 per group)

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