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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

Fig. 2

Treatment with sulforaphane restores learning ability in the Y maze and motor coordination in hyperammonemic rats. Control (C) and hyperammonemic (HA) rats treated with vehicle (V) or sulforaphane (SFN) were subjected to the conditional discrimination learning test in the Y maze (a) and the beam walking (b) tests. Values are the mean ± SEM of 11 rats per group in (a) and 22 rats per group in (b). Values significantly different from control rats are indicated by asterisks. Values significantly different from hyperammonemic rats are indicated by “a”. *p < 0.05; **p < 0.01; “ap < 005; “aap < 0.01

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