Fig. 8From: Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microgliaProposed sequences of events by which hyperammonemia-induced neuroinflammation leads to cognitive and motor impairment (in red) and treatment with sulforaphane restore them (in green). See details in “Discussion” sectionBack to article page