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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK

Fig. 6

Resveratrol regulates phosphorylation of MAPK via AMPK activation in vivo and in vitro. a Resveratrol downregulates the phosphorylation of MAPKs in vivo, including p38, ERK, and JNK; these effects were reversed by compound C. Compound C (30 μg/20 μl, i.t.) was coadministered. b Resveratrol increased p-JNK and p-ERK expression in primary astrocytes in a dose-dependent manner. c Resveratrol increased p-p38 and p-ERK expression in BV2 cells in a dose-dependent manner. Western blot bands and a data summary (n = 4 each group) are shown. *P < 0.05 and **P < 0.01 versus control; and # P < 0.05 and ## P < 0.01 versus the CCI group

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