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Fig. 9 | Journal of Neuroinflammation

Fig. 9

From: Blockage of indoleamine 2,3-dioxygenase regulates Japanese encephalitis via enhancement of type I/II IFN innate and adaptive T-cell responses

Fig. 9

Viral replication and innate immune responses of IDO-ablated microglia in response to JEV infection. Primary microglia recovered from BL/6 and IDO KO mice were infected with JEV at MOIs of 1.0 and 10 for viral replication and 10 for cytokine expression. JEV replication and the expression of cytokines, IFN-α/β, RLRs, ISGs, and IRF transcription factors were evaluated by real-time qRT-PCR using extracted total RNA at the indicated time point or 24 h pi. a JEV replication. b, c The expression of IFN-α/β and the ISG gene. d, e RLR and IRF expression. f TNF-α and IL-6 expression. The bar charts show the average ± SD of values derived from primary microglia assayed in quadruplicates

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