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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Tumor necrosis factor superfamily member APRIL contributes to fibrotic scar formation after spinal cord injury

Fig. 2

APRIL KO mice have a reduced fibrotic scar area after SCI. Two weeks following SCI, the fibrotic scar size was assessed in APRIL KO (df, n = 9) and WT (ac, n = 11) mice by evaluating the percent area of PDGFRβ signal within a 2-mm region centered around the injury site (g). The density of PDGFRβ+ cells was not different between WT and KO mice (h). Representative images from a WT and APRIL KO animal are shown with GFAP in red and PDGFRβ in green. n = biological replicates; *p < 0.05 compared to WT. Student’s t test. Scale bar = 250 μm

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