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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Neuron-immune mechanisms contribute to pain in early stages of arthritis

Fig. 7

Acute spinal blockade of P2X7 receptors (A-437089) or inhibition of cathepsin S (CatS) (LHVS) attenuated the enhanced mechanically evoked biceps femoris (BF) EMG responses in CIA rats at day 7. Representative mechanical stimulus-EMG response curve at 60 and 30 min after spinal treatment with A-437089 (a) or LHVS (b) in CIA rats. Time courses of the effects of a single spinal dose of the A-438079 (50 μg per rat) or saline on the magnitude of evoked BF EMG responses (c) or BF mechanical thresholds (e) in CIA rats 7 days post CIA immunization. Time courses of the effects of a single spinal administration of LHVS (50 nmol per rat) or vehicle (20 % Cremophor EL/saline) on the magnitude of evoked BF EMG responses (d) or BF mechanical thresholds (f) in CIA rats 7 days post-immunization. Values are mean ± SEM of 7–8 rats per group. ***p < 0.001, **p < 0.01, *p < 0.05 compared to control group (two-way RM ANOVA, post hoc Tukey’s test). In a and b, statistical analysis performed with AUC analysis and t test

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