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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease

Fig. 1

Expression and localization of TRPA1 channels in wild-type (WT) and APP/PS1 Tg mice. (a) Brains were harvested from WT and APP/PS1 Tg mice at 8 months old. Western blot analysis of protein levels of TRPA1 and α-tubulin. Data are mean ± SEM from 6 mice in each group. *, P < 0.05 vs. WT mice. (b, c) Immunohistochemistry of specimens of cortex and hippocampus from 8-month-old WT and APP/PS1 Tg mice with the antibodies anti-TRPA1, anti-vWF (endothelial cell marker), anti-NeuN (neuron marker), anti-GFAP (astrocyte marker) and anti-IBA-1 (microglia marker), then FITC- or Texas red-conjugated secondary antibody. Bar = 50 μm. vWF-positive cells denoted endothelial cells, NeuN-positive cells denoted neurons, and GFAP-positive cells denoted astrocytes, as indicated by arrowheads, stars or arrows, respectively

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