Fig. 9
From: Role of transient receptor potential ankyrin 1 channels in Alzheimer’s disease
TRPA1 − Ca2+ − PP2B signaling pathway in Aβ − triggered activation of NF-κB and NFAT and inflammation in astrocytes. A proposed mechanism by which TRPA1 channel regulates Aβ-mediated inflammatory response in astrocytes. Aβ fibril activates PP2B, NF-κB and NFAT and, ultimately, production of pro-inflammatory cytokines in astrocytes