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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Dimethyl fumarate attenuates experimental autoimmune neuritis through the nuclear factor erythroid-derived 2-related factor 2/hemoxygenase-1 pathway by altering the balance of M1/M2 macrophages

Fig. 2

DMF protects against peripheral nerve conduction deficits in EAN rats. Representative electrophysiological recordings of motor nerve compound muscle action potentials (CMAPs) evoked from stimulation of the fibular head (a) or ankle regions (b) of the sciatic nerve are shown for CMC, DMF-P, and DMF-T rats, respectively, from left to right. c Compared to the CMC group, DMF-treated groups were protected from EAN-induced damages of mean motor nerve conduction velocity (MNCV). d Compared to the CMC group, DMF-treated groups also exhibited better distal motor latencies of CMAPs. e DMF treatment improved the amplitude of CMAPs when compared to CMC groups, while we observed a non-significant trend. Comparisons between the CMC group and DMF-treated groups were performed using Mann–Whitney U tests. Data shown are the means ± SEM (*p < 0.05 for comparison between CMC and DMF-treated groups; n = 5–6). CMC vehicle control group, DMF-P preventative DMF group, DMF-T therapeutic DMF group. The experiment was repeated 3 times with similar results

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Journal of Neuroinflammation

ISSN: 1742-2094