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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain

Fig. 3

Effect of sildenafil citrate on the density of microglia/macrophages cells and COX-2 expression at 72 h after pMCAo. a Quantitative analysis of tomato-lectin (TL, n = 6–7 per group) in PBS, Sil-0.5, and Sil-10 (mg/kg)-treated animals. b–d Localization and quantification of COX-2+ cells in the core and/or the penumbra in PBS- and sildenafil-treated animals. ** p < 0.01, ***p < 0.001, sildenafil vs PBS treatment. ## p < 0.01, ### p < 0.001, sildenafil 0.5 vs sildenafil 10. Scale bar represents 100 μm (b) and 50 μm (enlarged panels)

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