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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Interactions between inflammatory mediators and corticosteroids regulate transcription of genes within the Kynurenine Pathway in the mouse hippocampus

Fig. 5

Three distinct Ido2 transcripts are expressed by hippocampal slice cultures, with IFNγ, LPS, pI:C, and Aldo inducing expression of specific Ido2 transcripts. OHSCs were treated with IFNγ, LPS, and pI:C ± Dex, Cort, or Aldo. Expression of Ido2 transcripts (a, d, g: Ido2-v1; b, e, h: Ido2-v2; c, f, i: Ido2-v3) are relative to control samples normalized to 1.0. *p ≤ 0.05 for the main effect of an inflammatory mediator; ϕ p ≤ 0.05 for the main effect of Dex, Cort, or Aldo; δ p ≤ 0.05 post hoc analysis for an interaction effect for Dex, Cort, or Aldo within inflammatory mediator

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Journal of Neuroinflammation

ISSN: 1742-2094