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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: A possible role of microglia-derived nitric oxide by lipopolysaccharide in activation of astroglial pentose-phosphate pathway via the Keap1/Nrf2 system

Fig. 7

The effects of hypoxia. Hypoxia enhanced PPP flux in microglia-containing and microglia-depleted astroglia, but did not alter NO production. Astroglia containing microglia (a PPP) and lacking in microglia (b PPP) had been exposed to 1 % hypoxia for 12 h prior to PPP measurement. Values are means ± SD of four flasks. *P < 0.05, ***P < 0.001 versus normoxia control (grouped t test). Astroglia with (open columns) or without (striped columns) microglia were exposed to 1 % hypoxia and LPS (0.01 μg/mL) prior to NO measurement. Hypoxia did not induce NO production in microglia-depleted astroglia and did not elicit increases in NO production in microglia-containing astroglia (d NO) as compared with normoxic control (c NO). Values are mean ± SD of six wells. *P < 0.05, ***P < 0.001 versus control (grouped t test)

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Journal of Neuroinflammation

ISSN: 1742-2094