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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Decreased neuroinflammation correlates to higher vagus nerve activity fluctuations in near-term ovine fetuses: a case for the afferent cholinergic anti-inflammatory pathway?

Fig. 2

a Presence of α7nAChR in near-term ovine brain was confirmed by Western blot. b Effect of UCO, microglia status and brain regions on HMGB1 translocation: significant group*brain region*microglia status interaction (p < 0.001). See Additional file 1: Table S1 for details. c Effect of UCO and microglia status on α7 nAChR immunofluorescence measured as intensity per area: significant group*microglia status*HMGB1 translocation interaction (p < 0.001). See Additional file 1: Table S2 for details. Note that, for α7 nAChR signal, between-brain region comparisons were not possible, because gain settings were optimized for each brain region and kept constant between cell compartment and groups (but not from region to region). HMGB1 signal is expressed as ratio of cytosolic to nuclear signal, i.e., the higher the ratio, the more HMGB1 translocation is observed; this normalization permits between-brain region comparisons

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Journal of Neuroinflammation

ISSN: 1742-2094