Table 2 Genotype and allele frequencies of the associated pro-inflammatory cytokine genes and their functional significance score

IL1A -889G>A

GG

102 (0.42)

118 (0.49)

G

313 (0.64)

344 (0.71)

rs1800587

GA

109 (0.45)

108 (0.44)

0.04

0.017^a

A

175 (0.36)

142 (0.29)

0.026

0.21

AA

33 (0.14)

17 (0.07)

^a2.1 (1.08–4)

1.36 (1.04–1.8)

IL6 -597G>A

GG

165 (0.67)

149 (0.61)

G

402 (0.82)

382 (0.78)

rs1800797

GA

72 (0.29)

84 (0.34)

0.38

A

90 (0.18)

106 (0.22)

0.18

AA

9 (0.04)

11 (0.05)

IL6 -572G>C

GG

62 (0.25)

81 (0.33)

G

268 (0.54)

273 (0.56)

rs1800796

GC

144 (0.59)

111 (0.45)

0.015

0.003^b

C

224 (0.46)

215 (0.44)

0.64

CC

40 (0.16)

52 (0.21)

^b1.7 (1.18–2.42)

IL6 -174G>C

GG

177 (0.72)

153 (0.63)

G

415 (0.84)

385 (0.79)

rs1800795

GC

61 (0.25)

79 (0.33)

0.10

0.034^c

C

77 (0.16)

101 (0.21)

0.04

0.40

CC

8 (0.03)

11 (0.05)

^c1.5 (1.03–2.2)

1.4 (1.02–1.96)

TNFA -308G>A

GG

202 (0.82)

192 (0.78)

G

443 (0.9)

435 (0.89)

rs1800629

GA

39 (0.16)

51 (0.21)

0.09

A

49 (0.1)

53 (0.11)

0.64

AA

5 (0.02)

1 (0.01)

TNFA -238G>A

GG

199 (0.80)

216 (0.89)

G

445 (0.9)

457 (0.94)

rs361525

GA

47 (0.19)

25 (0.1)

0.019

0.006^d

A

49 (0.1)

29 (0.06)

0.02

0.21

AA

1 (0.01)

2 (0.01)

^d2.05 (1.2–3.45)

1.74 (1.08–2.8)

IFNG +3232A>G

AA

85 (0.35)

61 (0.25)

A

285 (0.58)

265 (0.55)

rs2069718

AG

115 (0.47)

143 (0.59)

0.026

0.009^f, ^f1.6 (1.1–2.29)

G

203 (0.42)

221 (0.45)

0.22

ND

GG

44 (0.18)

39 (0.16)

0.019^e, ^e1.6 (1.08–2.36)

IFNG +874A>T

AA

96 (0.39)

107 (0.44)

A

300 (0.61)

316 (0.65)

rs2430561

AT

108 (0.44)

102 (0.42)

0.40

0.40

T

192 (0.39)

168 (0.35)

0.16

TT

42 (0.17)

33 (0.14)