Skip to main content

Table 2 Genotype and allele frequencies of the associated pro-inflammatory cytokine genes and their functional significance score

From: Pro-inflammatory cytokines and their epistatic interactions in genetic susceptibility to schizophrenia

Polymorphism Genotype Patients Controls P value Model-based P value/OR (CI) Allele Patients Controls P value/OR (CI) FS score
IL1A -889G>A GG 102 (0.42) 118 (0.49)    G 313 (0.64) 344 (0.71)   
rs1800587 GA 109 (0.45) 108 (0.44) 0.04 0.017a A 175 (0.36) 142 (0.29) 0.026 0.21
  AA 33 (0.14) 17 (0.07)   a2.1 (1.08–4)     1.36 (1.04–1.8)  
IL6 -597G>A GG 165 (0.67) 149 (0.61)    G 402 (0.82) 382 (0.78)   
rs1800797 GA 72 (0.29) 84 (0.34) 0.38   A 90 (0.18) 106 (0.22) 0.18  
  AA 9 (0.04) 11 (0.05)        
IL6 -572G>C GG 62 (0.25) 81 (0.33)    G 268 (0.54) 273 (0.56)   
rs1800796 GC 144 (0.59) 111 (0.45) 0.015 0.003b C 224 (0.46) 215 (0.44) 0.64  
  CC 40 (0.16) 52 (0.21)   b1.7 (1.18–2.42)      
IL6 -174G>C GG 177 (0.72) 153 (0.63)    G 415 (0.84) 385 (0.79)   
rs1800795 GC 61 (0.25) 79 (0.33) 0.10 0.034c C 77 (0.16) 101 (0.21) 0.04 0.40
  CC 8 (0.03) 11 (0.05)   c1.5 (1.03–2.2)     1.4 (1.02–1.96)  
TNFA -308G>A GG 202 (0.82) 192 (0.78)    G 443 (0.9) 435 (0.89)   
rs1800629 GA 39 (0.16) 51 (0.21) 0.09   A 49 (0.1) 53 (0.11) 0.64  
  AA 5 (0.02) 1 (0.01)        
TNFA -238G>A GG 199 (0.80) 216 (0.89)    G 445 (0.9) 457 (0.94)   
rs361525 GA 47 (0.19) 25 (0.1) 0.019 0.006d A 49 (0.1) 29 (0.06) 0.02 0.21
  AA 1 (0.01) 2 (0.01)   d2.05 (1.2–3.45)     1.74 (1.08–2.8)  
IFNG +3232A>G AA 85 (0.35) 61 (0.25)    A 285 (0.58) 265 (0.55)   
rs2069718 AG 115 (0.47) 143 (0.59) 0.026 0.009f, f1.6 (1.1–2.29) G 203 (0.42) 221 (0.45) 0.22 ND
  GG 44 (0.18) 39 (0.16)   0.019e, e1.6 (1.08–2.36)      
IFNG +874A>T AA 96 (0.39) 107 (0.44)    A 300 (0.61) 316 (0.65)   
rs2430561 AT 108 (0.44) 102 (0.42) 0.40 0.40 T 192 (0.39) 168 (0.35) 0.16  
  TT 42 (0.17) 33 (0.14)        
  1. FS score functional significance score
  2. aRecessive model (AA vs. GG+GA); bAdditive model (GC vs. GG+CC); cRecessive model (GG vs. GC+CC); dAdditive model (GA vs. GG+AA); eRecessive model (AA vs. AG+GG); fAdditive model (AG vs. AA+GG)