Fig. 2
From: Induction of the type I interferon response in neurological forms of Gaucher disease
Induction of the JAK/STAT pathway in nGD. a P-Stat2 is increased in the nGD brain. Double immunofluorescence of cortical layer V in 16-day-old mice using anti-P-Stat2 (red) and anti-MAC2 (green, upper and middle panels) or anti-NeuN (green, lower panel) antibodies and the nuclear marker, DAPI (blue). Arrows indicate nuclear staining of P-Stat2. Scale bar, 25 μm. Results are representative of three experiments. b Microarray analysis of ISG expression in the nGD brain. Data is presented as fold change of mRNA levels (Gba −/− versus Gba +/–). Values are means ± s.e.m, n = 3. *p < 0.05, **p < 0.05, ***p < 0.005. Janus kinase (JAK); signal transducer and activator of transcription (STAT)