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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Interferon gamma protects neonatal neural stem/progenitor cells during measles virus infection of the brain

Fig. 6

Impact of MV infection on expression of NSPC, neuronal, and glial markers in the hippocampus. Whole tissue lysates of hippocampal explants from CD46+ (ad) and CD46+/IFNγ-KO (eh) control and MV-infected mice were analyzed by Western Blots for Nestin (NSPC; ae), DCX (early neuron; b, f), βIII-tubulin (mature neuron; c, g) and GFAP (astrocyte; d, h) proteins. Integrated intensity values for each band, which are proportional to the sum of the fluorescent signal (measured in pixels) enclosed by the region of interest, are normalized to GAPDH as a protein loading control. Changes in nestin and DCX hippocampal protein expression correspond with changes in cell number observed for whole-brain cell isolates. *p < 0.01 significantly different uninfected versus MV-infected; #p < 0.05 significantly different between dpi

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