Fig. 2

The effect of low doses of LPS on behavioural outcomes at 24 and 48 hours post-challenge innaïve mice. Animals were subjected to a single dose of LPS: 0.1 mg/kg or 0.5 mg/kg (n=7 in each group)or vehicle administration (n=6), and were tested 24 h or 48 h thereafter in the elevated O-maze for (a) latency to exit to open arm, (b) number of exits into open arms, and (c) the time spent in the open arms. Subsequently, mice were observed for (d) latency and (e) duration of social interaction in a resident-intruder test. Mean speed (f) was also recorder in the open field. Data are mean ± SEM; *p < 0.05 when compared to control animals