Skip to main content


Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice

Fig. 3

The effect of low-dose LPS on depressive-like behaviours in stressed mice. Naïve and stressed animals were subjected to either a single dose of LPS (0.1 mg/kg) or vehicle injection and tested 24 h thereafter in a two-bottle sucrose preference test investigating a overall preference for sucrose, b total sucrose consumption, c water intake in a sucrose test, d the period of immobility in the tail suspension test, and in the forced swim test for e latency to floating and f total time spent floating. All animals showed >65 % preference for sucrose at baseline and similar sucrose preference prior to bolus injection of LPS or vehicle (Additional file 1: Figure S2). Data are mean ± SEM; *p < 0.05, **p < 0.01 and ***p < 0.001 when compared to controls; +p < 0.05 and +++p < 0.001 compared to stressed animals

Back to article page