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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice

Fig. 4

The effect of low-dose LPS on anxiety and aggression-like behaviours in stressed mice. Naïve and stressed animals were challenged with a single dose of LPS (0.1 mg/kg) or vehicle (saline) and tested 24 h thereafter in the elevated O-maze for the a latency to exit to the open arms and b number of exits to the open arms; in the resident-intruder paradigm for c duration of social interaction and d latency to attack conspecific, e total number of attacks and f duration of crawl over behaviour. Data are mean ± SEM; *p < 0.05, **p < 0.01 and ***p < 0.001 compared to control animals; +++p < 0.001 and ++++p < 0.0001 compared to stressed animals

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