Skip to main content
Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Complement system activation contributes to the ependymal damage induced by microbial neuraminidase

Fig. 8

Quantification of ependymal epithelium disruption in different experimental conditions. a The graph shows the proportion of disrupted ependyma relative to the total ependymal perimeter measured in histological sections. Four experimental situations were analyzed: sham-operated rats (SHAM), NA-injected wild-type rats (WT-NA), NA-injected C5-inhibitor-treated rats (INH-NA), and NA-injected C6-deficient rats (C6-NA). Photographs show the appearance of intact (b), damaged (c), and disrupted (d) ependymal epithelium immunostained with anti-vimentin. NA-injected WT rats display 53.5 ± 8.5 % of ependymal epithelium disruption. However, in rats with the complement system inhibited (IHN-NA and C6-NA), this proportion decreases significantly (11.3 ± 2.5 and 7.1 ± 3.3, respectively). Bars represent the mean ± SEM. Different treatments were compared by one-way ANOVA (F (3,11) = 25,872, P < 0.05) and Tukey’s range test. **P < 0.01. LV lateral ventricle, Ep ependyma, NP nervous parenchyma

Back to article page