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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Neuromyelitis optica study model based on chronic infusion of autoantibodies in rat cerebrospinal fluid

Fig. 1

Human IgG chronically infused in the rat brain ventricle widely diffused in the neural tissues. a Detection of human IgG in the rat brain, spinal cord, and optic nerve using immunohistochemistry (rat infused with IgGAQP4+2, D7 as and example). Scale bar 10 μm. Hip hippocampus, Cx cortex, CC corpus callosum, MB midbrain, ME median eminence, 3V third ventricle. b Detection of human immunoglobulin IgH and IgL chains (black arrows) accumulated in neural tissues of NMO-rats (received IgG-NMO) and Control-rats (received control IgG) ((asterisk) D7 and D14) using Western blot (actin as protein deposition control, same blot. Control: neural tissue from rat receiving saline buffer)

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Journal of Neuroinflammation

ISSN: 1742-2094