Fig. 7
Motor impairment in NMO-rat. Motor skills of the NMO-rats (red symbols, n = 10, rats infused with IgGAQP4+2) as compared to the Saline-rats (white symbols, n = 10). a Rotarod experiment measuring the latency to fall from the rotating rod at D3, D7, D10, D14, and D21 after IgG infusion, expressed as percent of D0 scores (latencies). The NMO-rats showed impairment in this task and fell much sooner from the rod than the Saline-rats. b Walking experiment measuring deviation from the linear trajectory initially chosen by the rat at D7, D14, and D21, expressed as percent of D0 shifts (*p < 0.05; **p < 0.01, ANOVA followed by post hoc tests). c Western blot analysis of the spinal cord of all rats at D21: altered expression of AQP4, GLT1, and pNF-H in the NMO-rats compared to the Control-rats